Hollywood is shutting down for the first time in over six decades.

160,000 television and movie actors who are members of The Screen Actors Guild - American Federation of Television and Radio Artists will go on strike at midnight, joining the thousands of screenwriters who have been on the picket line since May, per CNBC.

“What’s happening to us is happening across all fields of labor,” said Fran Drescher, SAG-AFTRA’s president, during a news conference Thursday. “When employers make Wall Street and greed their priority and they forget about the essential contributors who make the machine run, we have a problem.”

During the strike, actors will not be allowed to do rehearsals, auditions (including via self-tape), promote past projects through festivals, tours, premieres/screenings, interviews, and panels to name a few.

“We are the victims here,” Drescher added. “It is disgusting. . . Shame on them.”

The Alliance of Motion Picture and Television Producers, which represents on behalf of Hollywood companies, released a statement arguing that the union has “regrettably chosen a path that will lead to financial hardship for countless thousands of people who depend on the industry.”

As of right now, both sides are divided on several issues including pay and the use of artificial intelligence. The union is fighting to improve wages, health and pension benefits, as well as create boundaries for the use of artificial intelligence in future productions.

Meanwhile, The Writers Guild of America is aiming for an increase in pay and residuals in regards to streaming shows.

Viewers have already been affected by the strike after late-night shows like “The Late Show With Stephen Colbert,” “Jimmy Kimmel Live!” and “The Tonight Show Starring Jimmy Fallon” have gone more than two months without airing any new episodes.

Films in production, including “Deadpool 3” with Ryan Reynolds and Hugh Jackman, Ridley Scott's “Gladiator 2” and the video game sequel “Mortal Kombat 2”, immediately halted.